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目的了解我国供血员、受血者中经输血传播病毒（ＴＴＶ）感染率，及经输血传播ＴＴＶ的发生率。方法对１３０例输血者进行ＴＴＶ以及ＨＢＶ和ＨＣＶ血清标志物检测，其相应的供血者也检查ＴＴＶ。结果３４０例供血员中有３６例（１０．６％）可检测到ＴＴＶ－ＤＮＡ。１３０例受血者输血前有１１例（８．５％）ＴＴＶ阳性，其余１１９例输血后有１８例ＴＴＶ转为阳性，在他们的供血中至少可查到一份ＴＴＶ阳性。４６例输血后肝炎病毒感染者中，其中有４５例为ＨＣＶ感染（包括７例与ＴＴＶ混合感染），２例为ＨＢＶ感染（包括与ＨＣＶ、ＴＴＶ混合感染各１例）。ＴＴＶ与ＨＢＶ混合感染以及７例ＴＴＶ与ＨＣＶ混合感染中有３例的受血者ＡＬＴ＞９０Ｕ／Ｌ，但是１０例单纯ＴＴＶ感染者，仅有２例伴有轻微的ＡＬＴ增高。结论供血员及住院病人中有较高的ＴＴＶ感染率，单纯ＴＴＶ感染与ＡＬＴ显著升高似乎并无关联。
Objective To understand the transfusion transmitted virus (TTV) infection rate among blood donors and recipients in China and the incidence of transfusion-transmitted TTV. Methods TTV and serum markers of HBV and HCV were detected in 130 blood transfusions. The corresponding donors also examined TTV. Results TTV-DNA was detected in 36 (10.6%) of the 340 donors. Among the 130 recipients, 11 (8.5%) were positive for TTV before blood transfusion, and 18 of the remaining 119 patients had positive TTV, and at least one TTV was positive in their blood supply. Among the 46 cases of hepatitis B virus infection after transfusion, 45 cases were HCV infection (including 7 cases with TTV mixed infection), and 2 cases were HBV infection (including 1 case with mixed infection of HCV and TTV). There were 3 cases of ALT>90 U/L in TTV and HBV mixed infection and 7 cases of mixed infection of TTV and HCV, but only 10 cases of pure TTV infection only had slight ALT elevation. Conclusions There is a high TTV infection rate among donors and inpatients. There appears to be no correlation between TTV infection and ALT elevation.