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实验采用细胞外记录技术观察了去甲肾上腺素 (NE)和 5 羟色胺 (5 HT)对大鼠下丘脑脑片弓状核神经元的电活动的影响。结果表明 :①NE可能直接通过所记录神经元表面的α1或肾上腺素能受体发挥它们的兴奋作用 ;②NE可能经间接的途径发挥其抑制作用 ,即NE可能首先通过α1或 β肾上腺素能受体激活一个局部阿片能中间神经元 ,然后打开可能与阿片受体共存于所记录神经元膜上的KATP通道而实现其抑制作用 ;③ 5 HT可能通过 5 HT1A /1B和 5 HT受体的其他亚型直接发挥其兴奋作用 ;④ 5 HT可能也通过 5 HT1A/1B和 5 HT受体的其他亚型激活一个局部抑制性GABA能中间神经元 ,然后所释放的GABA通过GABAA 受体和GABAB 受体抑制所记录的弓状核神经元的活动
The effects of norepinephrine (NE) and serotonin (5 HT) on the electrical activity of arcuate nucleus neurons in rat hypothalamus were observed by extracellular recording technique. The results showed that: ①NE may exert their excitatory effect directly through α1 or adrenergic receptors on the surface of recorded neurons; ②NE may exert its inhibitory effect through indirect pathway, that is, NE may first pass α1 or β adrenergic receptor Activation of a local opioid interneuron and then opening of KATP channels that may coexist with opioid receptors in the recorded neuronal membranes; 5 HT may be mediated by 5 HT1A / 1B and 5 HT receptors in other subtypes 5 HT may activate a locally inhibitory GABAergic interneuron through other subtypes of 5 HT1A / 1B and 5 HT receptors, and then release GABA via the GABAA receptor and the GABAB receptor Inhibits recorded activity of arcuate nucleus neurons