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目的研究宫颈上皮内瘤变(CIN)患者经宫颈电环切术(LEEP)治疗后高危型人乳头瘤病毒(HR-HPV)持续感染的相关因素分析。方法选择行LEEP治疗的CIN患者74例,术前行宫颈液基细胞学检测(TCT)、第二代杂交捕获试验(HC2)及阴道镜下活组织检查,术后6个月及12个月均复查TCT及HC2,如有TCT异常合并HC2阳性或者仅有HC2持续阳性者再次行阴道镜活检。采用Logistic回归分析术后HR-HPV持续感染的危险因素。结果患者术后12个月HR-HPV转阴63例,持续阳性11例,术前HR-HPV DNA≥100RLU/CO是术后HR-HPV持续感染的高危因素(P<0.05),且与年龄、是否绝经及CIN级别无关(P>0.05)。结论术前HR-HPV高负荷是术后HR-HPV持续感染的独立危险因素,术后应加强随访。
Objective To investigate the related factors of persistent infection of high risk human papillomavirus (HR-HPV) after cervical electrosurgery (LEEP) in patients with cervical intraepithelial neoplasia (CIN). Methods Totally 74 CIN patients undergoing LEEP were enrolled in this study. Cervical liquid-based cytology (TCT), second-generation hybridization capture (HC2) and colposcopic biopsy were performed preoperatively. Six months and 12 months after operation All were reviewed TCT and HC2, if TCT abnormal HC2-positive or HC2-only positive again colposcopy biopsy. Logistic regression analysis was used to analyze the risk factors of HR-HPV persistent infection. Results HR-HPV was negative in 63 cases and persistent positive in 11 cases at 12 months after operation. Preoperative HR-HPV DNA≥100 RLU / CO was the risk factor for persistent HR-HPV infection (P <0.05) , Whether menopause and CIN level (P> 0.05). Conclusion Preoperative HR-HPV high load is an independent risk factor for persistent HR-HPV infection after surgery. Postoperative follow-up should be strengthened.