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已知心肌细胞膜微粒体脂质(CMML)能易化钙离子从水到脂相的转运。奎尼丁能抑制这一转运过程。为进一步证明其他带含氮碱性基团的心血管药物是否也能抑制CMML易化钙离子转运过程。本文选用了常咯啉(C),磷酸咯啶(P),奎尼下(Q),乌头碱(A),调微Ⅱ号(莨菪类,T),和非含氮碱性药物成脉安(V),研究了它们对这种易化钙转运过程的影响。结果表明C,P,Q和A在30μg/ml时对这一过程的抑制均超过70％。V和T在相同浓度时抑制作用分别为37.8％和微弱作用·C,P和Q的抑制作用可能是它们治疗作用的生化基础。V和T的药理机制可能与以上药物不同。
Myocardial cell membrane microsomal lipids (CMML) are known to facilitate the transport of calcium ions from water to the lipid phase. Quinidine can inhibit this transit process. To further prove that other cardiovascular drugs with nitrogen-containing basic groups can also inhibit CMML facilitation of calcium transport. In this paper, we selected the following compounds: protoporphyrin (C), pyrophosphoric acid (P), quinolide (Q), aconitine (A) Verapamil (V) was used to study their effect on this facilitated calcium transport. The results showed that C, P, Q and A inhibited the process more than 70% at 30μg / ml. The inhibitory effects of V and T at the same concentrations were 37.8% and faintly respectively. The inhibitory effects of C, P and Q may be the biochemical basis of their therapeutic effects. The pharmacological mechanisms of V and T may differ from the above.