目的探讨中西医结合治疗耐药性儿童支原体肺炎的疗效观察及对血清IL-6、IL-8、IL-10的影响。方法选取2015年6月-2016年7月于该院治疗的耐药性支原体肺炎患儿96例,随机分为观察组和对照组,每组48例。两组患儿均行退热平喘、止咳化痰等常规药物基础治疗,对照组单纯予以阿奇霉素治疗,观察组在对照组基础上加用中药药方治疗。比较两组患儿的治疗总有效率及治疗前后患儿血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、白细胞介素-10(IL-10)水平和症状量化积分。结果观察组患儿治疗的总有效率明显高于对照组(P<0.05);观察组患儿治疗后血清IL-6、IL-8、IL-10水平明显低于对照组(P<0.05);观察组患儿治疗后症状量化积分均明显低于对照组(P<0.05)。结论中西医结合治疗耐药性儿童支原体肺炎疗效显著,能够降低患儿血清IL-6、IL-8、IL-10水平,减轻患儿的炎症反应,缓解患儿肺炎症状。 Objective To investigate the curative effect of Chinese medicine and western medicine in treating children with drug resistant Mycoplasma pneumonia and its effect on serum IL-6, IL-8 and IL-10. Methods A total of 96 children with drug-resistant mycoplasma pneumonia who were treated in our hospital from June 2015 to July 2016 were randomly divided into observation group and control group with 48 cases in each group. The two groups of children were given antipyretic and antiasthmatic, cough and phlegm and other conventional drugs based on treatment, the control group was treated with azithromycin, the observation group in the control group based on the use of Chinese medicine treatment. The total effective rate and the levels of serum interleukin-6, interleukin-8 and interleukin-10 (IL-10) and interleukin-10 Symptoms quantify the integral. Results The total effective rate of treatment group was significantly higher than that of the control group (P <0.05). The levels of IL-6, IL-8 and IL-10 in the observation group were significantly lower than those in the control group The scores of symptom scores in observation group were significantly lower than those in control group (P <0.05). Conclusion Integrative treatment of drug-resistant children with mycoplasma pneumonia significant effect, can reduce children’s serum IL-6, IL-8, IL-10 levels, reduce inflammation in children, relieve symptoms of pneumonia in children.