氨基糖苷抗生素因肾毒性限制临床使用。药物对肾脏的损害有两方面的原因,即药物本身以及使用药物的患者状况。所有的氨基糖苷类抗生素对肾脏毒性的机理是相同的,均是因近曲小管中的溶酶体中的磷酯酶和鞘髓磷酯酶,引起磷酯水解的未消化酯质体在髓部不断积累,导致溶酶体不断膨大进入细胞破坏膜的完整性,药物在肾皮质中浓度的增加是氨基糖苷药物的肾毒 Aminoglycoside antibiotics are limited in clinical use due to nephrotoxicity. The damage to the kidneys caused by the drug can be caused by two factors, namely the drug itself and the condition of the patient who is using the drug. All aminoglycoside antibiotics on the toxicity of the kidney are the same mechanism, are due to proximal tubule lysosomal phosphatase and sphingomyelinase, causing phospholipid hydrolysis of undigested plastids in the pulp Ministry continue to accumulate, leading to lysosomes continue to expand into the cell damage the integrity of the film, the increase in drug concentration in the renal cortex is aminoglycoside drug nephrotoxicity