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本文作者报道了对70年代输血传播病毒研究组(TTVS)贮藏的血清标本检测丙型肝炎病毒抗体(抗-HVC)的情况.标本来自1974年至1979年输血的和医院未输血患者的血清,诊断和病程相同(对照病例).血清标本每隔2-3周收集1次,共6个月,随访至少10个月.诊断肝炎需至少1次血清丙氨酸氨基转移酶(ALT)活性大于90U/L以及3至17天后第二次复查大于45U/L.NANB型肝炎诊断的根据是无急性甲型肝炎病毒、乙型肝炎病毒(HBV)感染和任何非病毒病原血清学改变的证据.HCV抗体(抗-HCV)检测用重组多肽病毒抗原和人过氧化物歧化酶.用放射标记第2抗体测定反应活性.所有标本均以编码进行.结果表明,5名住院对照者在外科手术治疗后
The authors report the detection of hepatitis C virus antibodies (anti-HCV) in serum samples stored in the Transfusion-Transmitted Virus Research Group (TTVS) in the 1970s, from sera transfused in hospitals between 1974 and 1979 and not transfused in hospitals, The diagnosis and course of disease were the same (control case) Serum samples were collected once every 2 to 3 weeks for a total of 6 months for a minimum of 10 months.At least 1 serum ALT activity was required to diagnose hepatitis 90U / L and a second review greater than 45U / L after 3 to 17 days The basis for the diagnosis of NANB is evidence of absence of acute hepatitis A, hepatitis B virus (HBV) infection and any non-viral pathogenic serological changes. The HCV antibody (anti-HCV) assay used recombinant polypeptide virus antigens and human superoxide dismutase. Reactivity was measured by radiolabeled secondary antibody. All samples were coded. The results showed that 5 hospital controls were treated surgically Rear