目的 :进一步认识淋巴源性肿瘤的超微结构形态改变的特征。方法 :对一组淋巴源性肿瘤 (包括急性淋巴细胞白血病、B细胞 -慢性淋巴细胞白血病、大颗粒淋巴细胞白血病、T细胞 -幼淋巴细胞白血病、毛细胞白血病、伴绒毛淋巴细胞脾淋巴瘤、白血病 -淋巴瘤、多发性骨髓瘤 )在透射电镜 (TEM)下观察其形态改变并进行了分析。结果 :部分疾病具有独特的超微结构形态改变 ,一些光镜下难以区别的疾病有可能得到鉴别 ,TEM对某些瘤细胞的识别有独到之处。结论 :TEM检查对淋巴系统肿瘤的诊断是一有用的工具。 Objective: To further understand the characteristics of ultrastructural changes in lymphoid tumors. Methods: A panel of lymphoid tumors (including acute lymphoblastic leukemia, B-cell chronic lymphocytic leukemia, large granulocytic leukemia, T-lymphocytic leukemia, hairy cell leukemia, lymphoma with splenic lymphoma, Leukemia - lymphoma, multiple myeloma) were observed under transmission electron microscope (TEM) morphological changes and were analyzed. Results: Some diseases have unique morphological changes of ultrastructure. Some diseases which are difficult to be distinguished under light microscope may be identified. Some of the tumor cells are identified by TEM. Conclusion: TEM examination is a useful tool for the diagnosis of lymphatic system tumors.