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目的:探讨单次高负荷剂量阿托伐他汀对阵发性心房颤动患者高敏C反应蛋白(hs-CRP)水平和转复成功率的影响。方法:79例急性心肌梗死合并心房颤动发作患者随机分为高负荷剂量阿托伐他汀组和对照组,均给予胺碘酮进行药物复律,检测患者用药前,用药后24 h、72 h、7 d的hs-CRP水平。结果:高负荷剂量阿托伐他汀组在各时间点上复律成功率均显著高于对照组;高负荷剂量阿托伐他汀组在用药后24 h即出现hs-CRP显著下降,在各时间点上均低于对照组。结论:胺碘酮复律前给予高负荷剂量阿托伐他汀能迅速降低阵发性心房颤动患者hs-CRP水平,提高转复成功率。
Objective: To investigate the effect of single high-dose atorvastatin on hs-CRP level and successful rate of recovery in patients with paroxysmal atrial fibrillation. Methods: A total of 79 patients with acute myocardial infarction complicated with atrial fibrillation were randomly divided into high-load atorvastatin group and control group. All patients were given amiodarone for drug cardioversion. Before treatment, the patients were treated for 24 h, 72 h, 7 h hs-CRP levels. Results: The successful rate of cardioversion in high-dose atorvastatin group was significantly higher than that in control group at each time point. The hs-CRP in high-dose atorvastatin group decreased significantly at 24 h after treatment, Point lower than the control group. Conclusions: Atorvastatin administered before amiodarone cardioversion can reduce the hs-CRP level and improve the success rate of recovery in patients with paroxysmal atrial fibrillation.