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本文用家兔急性高眼压模型测定了急性高眼压后不同时期视网膜的ＳＯＤ、ＣＡＹ活性和ＭＤＡ含量，并用ＥＳＲ测定了急性高眼压视网膜自由基的波谱，同时用透射电镜观察了急性高眼压后不同时期及应用自由基清除剂ＶｉｔＥ、ＶｉｔＣ后视网膜的超微结构变化，发现急性高眼压后ＳＯＤ、ＣＡＴ活性降低，而ＭＤＡ含量增高，ＥＳＲ波谱ｇ值２．００１６５，为氧自由基。超微结构显示视细胞盘膜扭曲，内段线粒体膨胀。应用自由基清除剂ＶｉｔＥ、Ｃ后，上述改变明显减轻，揭示急性闭角型青光眼发作后，在降低眼压同时，在相当长时间内应用自由基清除剂，以减轻视功能和结构损伤是非常必要的。
In this paper, the rabbit model of acute ocular hypertension was used to measure the activity of SOD and CAY and the content of MDA in retina at different periods after acute intraocular hypertension. The ESR was used to measure the spectrum of retinal free radical in acute intraocular hypertension. The acute high intraocular pressure Intraocular pressure at different stages and the application of free radical scavengers VitE, VitC ultrastructural changes after the retina found that acute high intraocular pressure after SOD, CAT activity decreased, while the MDA content increased, ESR spectrum g value 2.00165, for the oxygen free base. The ultrastructure shows that the optic disc is distorted and the inner segment mitochondria swell. The application of free radical scavenger VitE, C, the change was significantly reduced, revealing acute angle-closure glaucoma after reducing intraocular pressure in the same time, the application of free radical scavenger for a long time to reduce visual function and structural damage is very necessary.