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目的探讨阿托伐他汀联合曲美他嗪治疗冠状动脉粥样硬化性心脏病患者的临床效果。方法选取辽宁省锦州市第二医院接诊的冠状动脉粥样硬化性心脏病患者96例为研究对象,将其按随机数字表法分为联合治疗组与曲美他嗪治疗组,各48例,分别运用阿托伐他汀与曲美他嗪联合用药和曲美他嗪单一用药进行治疗,观察两组患者临床疗效与心功能指标变化。结果联合治疗组患者总有效率为95.8%,曲美他嗪治疗组患者总有效率为87.5%,差异有统计学意义(P<0.05);联合治疗组患者治疗后LVEDD、LVESD显著低于对照组,LVEF、E/A高于曲美他嗪治疗组,差异均有统计学意义(均P<0.05)。结论阿托伐他汀联合曲美他嗪治疗冠状动脉粥样硬化性心脏病患者临床效果确切,还能有效改善患者的心功能。
Objective To investigate the clinical effect of atorvastatin combined with trimetazidine in patients with coronary atherosclerotic heart disease. Methods Ninety-six patients with coronary atherosclerotic heart disease admitted to the Second Hospital of Jinzhou, Liaoning Province were selected as the research object. They were divided into the combination therapy group and the trimetazidine treatment group according to the random number table method, each 48 cases , Were treated with atorvastatin and trimetazidine combination therapy and trimetazidine single treatment, the clinical efficacy and cardiac function changes in two groups were observed. Results The total effective rate was 95.8% in the combined treatment group and 87.5% in the trimetazidine group (P <0.05). The LVEDD and LVESD in the combined treatment group were significantly lower than those in the control group Group, LVEF, E / A were higher than trimetazidine treatment group, the difference was statistically significant (all P <0.05). Conclusion Atorvastatin combined with trimetazidine treatment of coronary atherosclerotic heart disease in patients with exact clinical effect, but also can effectively improve the patient’s cardiac function.