由疟原虫引起的疟疾是严重威胁人类健康的传染性疾病之一,疟原虫基因组序列的测定,有利于疫苗及抗疟新药的研制。 恶性疟原虫基因组长30mb,A+T的含量为82％,共有14个染色体。2号染色体全序列的测定采用鸟枪测序法测得。全序列长947kb,A+T的含量为80.2％,包括一个大的编码单拷贝基因和几个双拷贝基因的中心区,以及一个含有变异的抗原基因、重复散 Malaria caused by Plasmodium is one of the infectious diseases that seriously threaten human health. The determination of the genome sequence of Plasmodium is beneficial to the development of vaccine and new antimalarial drug. Plasmodium falciparum genome length 30mb, A + T content of 82%, a total of 14 chromosomes. The complete sequence of chromosome 2 was determined by shotgun sequencing. The full-length sequence is 947 kb in length and contains 80.2% A + T, including a large central region encoding a single-copy gene and several double-copy genes, as well as a variant antigen gene,