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磷酸腺苷活化的蛋白激酶(AMPK)是体内一种重要的蛋白激酶,广泛分布于全身各组织器官,在调节细胞能量代谢方面发挥着重要作用。AMPK上的苏氨酸172结合位点,以及该位点的磷酸化对其活性的调节发挥着至关重要的作用。对其与肿瘤相关性的深入研究发现,AMPK可被多种途径激活。AMPK及其上游激酶LKB1、钙调蛋白依赖性蛋白激酶的激酶(CaMKK)、转化生长因子β活化的蛋白激酶(TAK1)和丝氨酸/苏氨酸激酶(Akt/PKB)的活化对肿瘤细胞的增殖、生长、侵袭和转移具有复杂的调控作用,有望成为卵巢癌化疗作用中的新靶点。对AMPK在卵巢肿瘤中的研究综述。
AMPK, an important protein kinase in the body, is widely distributed in various tissues and organs of the body and plays an important role in the regulation of cellular energy metabolism. The threonine 172 binding site on AMPK, as well as the phosphorylation of this site, plays a crucial role in the regulation of its activity. In-depth study of its correlation with tumor found that AMPK can be activated by a variety of pathways. Activation of AMPK and its upstream kinase LKB1, calmodulin-dependent protein kinase kinase (CaMKK), transforming growth factor beta-activated protein kinase (TAK1) and serine / threonine kinase (Akt / PKB) on tumor cells , Growth, invasion and metastasis with a complex regulatory role, is expected to become a new target for the role of chemotherapy in ovarian cancer. Study Summary of AMPK in Ovarian Tumors.