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乳酸脱氢酶C(LDHC)是目前已知的最早在男性生精细胞中发现的睾丸特异同功酶。LDHC最早通过凝胶电泳技术在人精子及睾丸生精细胞中被发现。免疫组化结果显示LDHC最早出现在早期的粗线期初级精母细胞中,其数量随着减数分裂逐渐增加。成熟精子中LDHC主要定位在精子尾部的主段区域。研究显示,乳酸脱氢酶家族的同功酶在哺乳动物细胞中无所不在,他们受到发育的调控,具有组织细胞的特异性,且功能多样。本文就LDHC的发展史及他们在帮助精子完成受精过程中的作用作一综述。
Lactate dehydrogenase C (LDHC) is the earliest testicular-specific isozyme found in spermatogenic cells of male germ cells. LDHC was first detected in human spermatozoa and spermatogenic cells by gel electrophoresis. Immunohistochemical results showed that LDHC first appeared in the early pachytene spermatocytes, the number increased gradually with meiosis. LDHC in mature sperm is mainly located in the main section of sperm tail. Studies have shown that the lactate dehydrogenase family of isozymes are ubiquitous in mammalian cells, they are regulated by development, have tissue cells specificity and are versatile. This review summarizes the history of LDHCs and their role in helping sperm to complete fertilization.