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Objective:The present study is to compare pharmacokinetics difference of carboplatin by using ultraselection uterine artery with by using peripheral vein in cervical cancer. Methods:Thirteen patients with locally advanced cervical cancer who had been proved by pathobiology were randomly divided into two groups:the ultraselection uterine artery group (group A, n=6) and the peripheral vein (group B, n=7). Carboplatin was administered by infusing into artery or vein in both groups at the dosage of 300 mg/m2. Tissues from the cervical tumor were collected at different times after infusion in both groups and then analyzed. Results:The peak concentration of platinum in tumor tissue was about 2.79 times higher in group A than that of group B (P<0.05). The platinum concentrations in tumor in group A reached its peak levels immediately after infusion. But, group B had delayed time. While, for the time point of 0 min, when the administration finished immediately, the platinum concentration in tumor was significantly higher when compared with group B (P < 0.05). The tumor tissue area under the concentration (AUC) of carboplatin was about 2 times higher in group A than that of group B (P < 0.05). Conclusion:We observed the pharmacological advantages of chemotherapy by using ultraselection uterine artery administration of chemo-therapeutic agent carboplatin in tumor tissue which provided theoretical basis and laboratory parameters of the intra-arterial chemotherapy for gynecologic malignancy.