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研究了手性元 5 -( R) -( l-氧基 ) -2 ( 5 H ) -呋喃酮与取代苯甲醛肟以次氯酸钙作为氧化剂进行的区域选择性原位 1 ,3 -偶极环加成反应 ,同步生成两个新的手性中心 ,得到了一系列光学纯丁内酯并 [3 ,4-d]-3 -取代基 -异唑啉类化合物 ;应用波谱学手段及 X射线单晶衍射法确证了产物的绝对构型 ,并对产物的核磁共振氢谱规律性加以总结 .
In this paper, we studied the regioselectivity of the regioselective in situ 1,3 - dihydroxy - 5 - (R) - (l-acenaphthoxy) -2 (5H) - furanone with substituted benzaldoxime using calcium hypochlorite as oxidant. Dipole cycloaddition reactions were performed to generate two new chiral centers synchronously. A series of optical pure butyrolactone [3, 4-d] -3-substituent-isoxazoline compounds were obtained. Means and X-ray single crystal diffraction confirmed the absolute configuration of the product, and the product of the nuclear magnetic resonance spectroscopy to summarize the law.