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目的:探讨重组脑钠肽对急性失代偿性心力衰竭患者炎症因子及肾素系统的影响。方法:选择2014年7月~2016年7月于我院就诊的急性失代偿性心力衰竭患者160例,80例对照组行硝普钠治疗,80例实验组行重组脑钠肽治疗,观察两组治疗前后肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、脑钠肽(BNP),醛固酮、血管紧张素Ⅱ、血浆肾素活性,血流动力学变化及心功能情况。结果:治疗前,实验组TNF-α、hs-CRP、IL-6、BNP低于对照组,差异有统计学意义(P<0.05)。实验组醛固酮、血管紧张素Ⅱ、血浆肾素活性低于对照组,差异有统计学意义(P<0.05)。实验组血流动力学低于对照组(P<0.05)。实验组心功能较对照组改善更明显(P<0.05);实验组副反应少于对照组(P<0.05)。结论:急性失代偿性心力衰竭患者应用重组脑钠肽治疗可降低患者炎症因子,改善肾素系统。
Objective: To investigate the effect of recombinant brain natriuretic peptide on inflammatory factors and renin system in patients with acute decompensated heart failure. Methods: From July 2014 to July 2016, 160 patients with acute decompensated heart failure admitted to our hospital, 80 patients in the control group were treated with sodium nitroprusside and 80 patients in the experimental group were treated with recombinant brain natriuretic peptide. The levels of TNF-α, hs-CRP, IL-6, BNP, aldosterone, angiotensin Ⅱ , Plasma renin activity, hemodynamic changes and cardiac function. Results: Before treatment, the levels of TNF-α, hs-CRP, IL-6 and BNP in the experimental group were significantly lower than those in the control group (P <0.05). The levels of aldosterone, angiotensin Ⅱ and plasma renin in the experimental group were lower than those in the control group (P <0.05). The hemodynamics of the experimental group was lower than that of the control group (P <0.05). The cardiac function in experimental group improved more obviously than that in control group (P <0.05). The side reaction in experimental group was less than that in control group (P <0.05). Conclusion: The treatment of patients with acute decompensated heart failure with recombinant brain natriuretic peptide can reduce the inflammatory cytokines and improve the renin system.