目的探讨成功实行介入封堵治疗的左向右分流先天性心脏病即房间隔缺损在封堵前后即刻.随访期间肺动脉压力的变化规律。方法 500例成功施行介入治疗的患者.经导管测定术前及封堵后即刻肺动脉压力.并对肺动脉压力在介入治疗前后进行对比研究。结果①正常/轻度肺动脉高压组:PASP.PAMP在封堵即刻后均轻度升高.前者升高有统计学差异(P<0.05)。②中度肺高压组PASP和PAMP在封堵即刻后均明显降低(P<0.05)。结论①PH是ASD常见、且严重的并发症,肺动脉压力是其手术时机选择、疗效判断和预后的重要指标。监测肺动脉压力变化.探讨其变化规律对合并PH的ASD的诊断和治疗均具有重要的临床意义。②用肺动脉频谱法可以较准确地估测肺动脉压力.其对于PH的ASD具有重要诊断价值。③经导管封堵治疗合并PH的ASD是安全、有效的,介入治疗能明显降低中.重度肺动脉高压. Objective To investigate the changes of pulmonary arterial pressure during the follow-up of patients with left atrial-to-right shunt congenital heart disease (ASD), which is successfully performed with interventional occlusion. Methods A total of 500 patients undergoing successful PCI were enrolled in this study.The pulmonary artery pressure was measured preoperatively and immediately after balloon occlusion by catheterization, and pulmonary artery pressure was compared before and after interventional therapy. Results ① In the group of normal / mild pulmonary hypertension, PASP.PAMP increased slightly immediately after the occlusion, and there was a statistically significant difference between the two groups (P <0.05). ② PASP and PAMP in moderate pulmonary hypertension group were significantly decreased after occlusion (P <0.05). Conclusions ①PH is a common and serious complication of ASD. Pulmonary artery pressure is an important index of choice of timing, curative effect and prognosis. Monitoring changes in pulmonary artery pressure. To explore the changes in the rule of PHD in the diagnosis and treatment of ASD has important clinical significance. Pulmonary artery spectrum method can be more accurately estimated pulmonary artery pressure, which has important diagnostic value for PH ASD. ③ Transcatheter closure of PHD combined with ASD is safe and effective, interventional therapy can significantly reduce. Severe pulmonary hypertension.