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我们收治经遗传调查出3个家系中有8例母女、和姊妹同患SLE的病人,现报告如下。第一个家系:例1,女,38岁。以反复高热皮疹,3年后(1970年)肝大,肝功异常,面部色素性蝶形斑取病理确诊为SLE。以泼尼松反复治疗直至1985年(15年后)绝经期逐停药,病情稳定至今。例2(例1之女儿),16岁,以月经过多高热皮疹1975年始反复住院。3年后症状加重(血三系减少,血涂片找到大量狼疮细胞),而确诊为SLE,服泼尼松缓解,4年后病情恶化死于它院。例3(例1之妹),女,35岁,医生。1973年发病,高热皮疹、肝脾大肾损坏,血中找到大量SLE细胞,经治疗病情一度缓解,8年后死于心肾功能衰竭。第二个家系:例4,女,36岁。8年鱼鳞癣、4年偏头痛,高热贫血,以溶血收住院,经查确诊为SLE,经泼尼松治疗症状消失,3年后之症加重,于1990年第二次入院,经血浆置换治疗病
We have admitted to the genetic survey of 3 families in 8 mother and daughter, and sister with SLE patients, are as follows. The first pedigree: Example 1, female, 38 years old. To repeatedly hot rash, 3 years after (1970) hepatomegaly, abnormal liver function, facial pigmented butterfly spot pathology confirmed as SLE. Repeated treatment with prednisone until 1985 (after 15 years) by the withdrawal of menopause, the disease has stabilized. Example 2 (daughter of Example 1), 16 years old, with a high rate of hot rash on her menstrual repeated hospitalizations in 1975. After 3 years, the symptoms were aggravated (reduction of blood triad, blood smears found a large number of lupus cells), and diagnosed as SLE, prednisolone alleviated, 4 years later the condition deteriorated died of its hospital. Example 3 (Case 1, sister), female, 35 years old, doctor. In 1973, the incidence of high fever rash, liver and spleen damage, found a large number of SLE cells in the blood, the treatment of the condition was alleviated, died of heart and kidney failure after 8 years. The second family: Example 4, female, 36 years old. 8 years of ichthyosis, 4 years of migraine, fever, anemia, hemolytic admitted to hospital, confirmed by diagnosed as SLE, the symptoms disappeared after prednisone, 3 years after the disease aggravated in 1990, the second admission, the plasma exchange Treatment of disease