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采用免疫组化法对42例肾癌、20例癌旁正常肾组织MTS_1基因产物P_(16)蛋白进行检测。结果显示肾癌P_(15)蛋白表达阳性率明显高于癌旁正常肾组织(P<0.01),P_(16)表达相关于肾癌病理分级、临床分级及预后。结果提示:MTS_1基因与肾癌的发生发展有关,P_(16)蛋白表达缺失是肾癌恶性度高及晚期表现。P_(16)蛋白表达可作为判断肾癌预后的指标。
Immunohistochemistry was used to detect the protein P_ (16) of MTS_1 gene in 42 cases of renal cell carcinoma and 20 cases of adjacent normal tissues. The results showed that the positive rate of P 15 protein in renal cell carcinoma was significantly higher than that in adjacent normal renal tissues (P <0.01). The expression of P 16 was correlated with the pathological grade, clinical grade and prognosis of renal cell carcinoma. The results suggest that MTS_1 gene is associated with the occurrence and development of renal cell carcinoma. The loss of P_ (16) protein expression is the high malignant and advanced renal cell carcinoma. The expression of P_ (16) protein can be used as an index to judge the prognosis of renal cell carcinoma.