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应用重组人白细胞介素Ⅱ治疗10例慢性乙型肝炎患者以观察和评价其抗病毒作用。10例患者接受白细胞介素Ⅱ每日剂量1～3×10~5u,持续21～28天,全部按计划完成治疗。治疗期间,6例患者血清DNA多聚酶水平下降和4例转阴。但治疗停止后多数病例又增加到治疗前水平。治疗期中血清HBeAg水平无变化,有6例血清转氨酶水平暂时性增加,当停止治疗后即明显下降。介素Ⅱ的副作用包括发热、寒战、食饮不振及疲乏无
Ten patients with chronic hepatitis B were treated with recombinant human interleukin Ⅱ to observe and evaluate their antiviral effects. 10 patients received interleukin Ⅱ daily dose of 1 ~ 3 × 10 ~ 5u, lasted 21 to 28 days, all completed according to plan treatment. During treatment, serum DNA polymerase levels decreased in 6 patients and in 4 patients turned negative. However, most patients after treatment stopped increasing to pre-treatment levels. Serum HBeAg levels did not change during the treatment period, 6 cases of serum transaminase levels temporarily increased, when stopped after treatment decreased significantly. Side effects of IL include fever, chills, poor diet and fatigue