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目的:研究多囊卵巢综合征(PCOS)患者血清抗苗勒管激素(AMH)水平的变化及其与胰岛素抵抗(IR)和雄激素的关系。方法:回顾性分析85例PCOS患者及79例正常女性的体质量指数(BMI)、血清AMH、血糖、胰岛素、雄激素、稳态模型胰岛素抵抗指数(HOMA-IR)间的相互关系。血清AMH采用ELISA法测定,空腹血浆葡萄糖(FPG)采用葡萄糖氧化酶法测定,空腹胰岛素(FIns)采用化学发光法测定,睾酮(T)采用酶联免疫法测定。结果:PCOS组血清AMH水平明显高于对照组;Person相关分析表明,PCOS组血清AMH水平与HOMA-IR及BMI不相关,与雄激素、年龄相关。多元线性回归分析显示,PCOS组中血清雄激素水平是血清AMH的影响因素。结论:PCOS人群中血清AMH较正常女性升高,但其升高与IR无关,而与雄激素水平密切相关。
Objective: To investigate the changes of serum anti-Mullerian hormone (AMH) in patients with polycystic ovary syndrome (PCOS) and its relationship with insulin resistance (IR) and androgen. Methods: The relationship between body mass index (BMI), serum AMH, blood glucose, insulin, androgen, and homeostasis model insulin resistance index (HOMA-IR) were retrospectively analyzed in 85 PCOS patients and 79 normal women. Serum AMH was measured by ELISA, fasting plasma glucose (FPG) by glucose oxidase method, fasting insulin (FIns) by chemiluminescence and testosterone (T) by enzyme-linked immunosorbent assay. Results: The level of serum AMH in PCOS group was significantly higher than that in control group. Correlation analysis of Person showed that serum AMH levels in PCOS group were not related to HOMA-IR and BMI, and were related to androgen and age. Multiple linear regression analysis showed that serum androgen levels in PCOS group were the influencing factors of serum AMH. Conclusions: Serum AMH in PCOS patients is higher than that in normal women, but its elevation is not related to IR, but closely related to the level of androgen.