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1例17岁女性患者因肺结核给予吡嗪酰胺、乙胺丁醇、利福平、异烟肼治疗。2个月后吡嗪酰胺及乙胺丁醇停用,利福平0.45g/d和异烟肼0.3g/d继续应用。又过3个月,患者出现双下肢可凹性水肿,伴乏力、憋气、尿中泡沫多。遂停用利福平及异烟肼。实验室检查:血浆白蛋白(Alb)12.6g/L,血脂(TG)2.11mmol/L,24h尿蛋白5.511～8.283g,肌酐清除率(CCr)181ml/min。给予口服泼尼松龙、对症治疗,并给予吡嗪酰胺、乙胺丁醇、异烟肼巩固疗效。15d后症状好转出院,随访无复发。
A 17-year-old female patient was given pyrazinamide, ethambutol, rifampicin and isoniazid for pulmonary tuberculosis. Pyrazinamide and ethambutol were discontinued after 2 months and rifampin 0.45 g / d and isoniazid 0.3 g / d were continued. Another 3 months, patients with concave edema of both lower extremities, with fatigue, suffocation, urine foam. Then disable rifampicin and isoniazid. Laboratory tests included 12.6g / L of serum albumin (Alb), 2.11mmol / L of blood lipid (TG), 5.511-8.283g of urinary protein for 24 hours and 181ml / min of creatinine clearance rate (CCr). Given oral prednisolone, symptomatic treatment, and given pyrazinamide, ethambutol, isoniazid consolidation effect. 15d after symptoms improved discharge, no recurrence.