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目的:探讨2型糖尿病(T2DM)患者微血管病变与血清代谢学指标的关系。方法:选择我院于2015年7月~2016年7月间收治的T2DM患者共96例,按是否存在微血管病变分为观察组(n=43,存在微血管病变)及对照组(n=53,无微血管病变)。检测并对比两组患者血清中三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、糖化血红蛋白(HbA1C)、同型半胱氨酸(Hcy)、血清胱抑素C(CysC)及血管内皮生长因子(VEGF)水平,并采用logistic回归分析T2DM微血管病变的危险因素。结果:观察组病程、吸烟率高于对照组,差异有统计学意义(P<0.05);观察组TG、LDL、HbA1C、CysC、Hcy、VEGF水平均高于对照组,差异均有统计学意义(P<0.05);两组TC、HDL水平比较,差异无统计学意义(P>0.05);经logistic回归分析显示,病程、CysC、Hcy、VEGF为微血管病变的危险因素(OR=1.975,3.643,4.054,4.214,P<0.05)。结论:CysC、Hcy、VEGF为微血管病变的危险因素,对其水平的检测有助于早期T2DM微血管病变诊断及治疗。
Objective: To investigate the relationship between microangiopathy and serum metabolites in type 2 diabetes mellitus (T2DM). Methods: A total of 96 T2DM patients were selected from July 2015 to July 2016 in our hospital. The patients were divided into observation group (n = 43) and control group (n = 53) according to the presence or absence of microangiopathy. No microvascular disease). The levels of TG, TC, HDL, LDL, FBG, HbA1C, Hcy, CysC and VEGF in the patients with T2DM. The risk factors of T2DM microangiopathy were analyzed by logistic regression. Results: The duration of disease and smoking rate in the observation group were higher than those in the control group (P <0.05). The levels of TG, LDL, HbA1C, CysC, Hcy and VEGF in the observation group were significantly higher than those in the control group (P <0.05). There was no significant difference in TC and HDL levels between the two groups (P> 0.05). Logistic regression analysis showed that the duration of disease, CysC, Hcy and VEGF were risk factors of microvascular disease (OR = 1.975, , 4.054, 4.214, P <0.05). Conclusion: CysC, Hcy and VEGF are the risk factors of microangiopathy. The detection of CysC, Hcy and VEGF may contribute to the diagnosis and treatment of early stage T2DM microangiopathy.