Fourteen cases of pulmonary tuberculosiswith smear negative sputum confirmed by fiber-optic bronchoscopy (FB) examination were re-ported. The reasons for the misdiagnosis wereneoplasm simulating tuberculosislesion in FBexamination, solitary tubercu lous cavitation Fourteen cases of pulmonary tuberculosis with smear negative sputum confirmed by fiber-optic bronchoscopy (FB) examination were re-ported. The reasons for the misdiagnosis wereneoplasm simulating tuberculosislesion in FBexamination, solitary tubercu lous cavitation