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目的探讨慢性乙型肝炎(CHB)患者代谢异常的表现形式。方法分析110例CHB患者各代谢指标的异常率。结果 1)CHB中93.64%存在HOMA-β减退,60.00%者平均减退70.00%以上;2)59.09%患者HOMA-IR升高,平均1.82;3)35.45%有糖代谢异常;4)52.73%至少有一种血脂成份异常,以HDL-c异常常见;5)少部份患者合并脂肪肝、高血压病或高尿酸血症。结论 CHB患者普遍存在胰岛β细胞功能减退及不同程度的胰岛素抵抗,糖脂代谢异常及脂肪肝亦常见,少见高血压及尿酸代谢异常。
Objective To investigate the manifestations of metabolic abnormalities in patients with chronic hepatitis B (CHB). Methods The abnormal rate of each metabolic index in 110 CHB patients was analyzed. Results: 1) HOMA-βdecreased in 93.64% of CHB patients, with an average decrease of 70.00% in 60.00%; 2) HOMA-IR increased in 59.09% of patients with an average of 1.82; 3) 35.45% had glucose metabolism abnormalities; 4) 52.73% There is an abnormal lipid composition to HDL-c abnormalities common; 5) a small number of patients with fatty liver, hypertension or hyperuricemia. Conclusion The prevalence of pancreatic β-cell dysfunction and varying degrees of insulin resistance, abnormal glucose and lipid metabolism and fatty liver are common in patients with CHB, with rare hypertension and abnormal uric acid metabolism.