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[目的]观察辛伐他汀和缬沙坦合用在轻中度原发性高血压患者的长期治疗过程中的临床疗效和安全性。[方法]103例轻中度原发性高血压病患者均是来自我院门诊病例,通过记录的随机号数字表产生分组随机号,分为治疗组53例,对照组50例,治疗组缬沙坦和辛伐他汀合用,对照组缬沙坦单用,用药10周后进行疗效分析。[结果]治疗组总有效率达97.1%,对照组总有效率84.0%,两组间疗效差异有统计学意义(P﹤0.05)。两组治疗后较治疗前比较偶测血压、24h、日间、夜间平均血压均下降(P﹤0.01),TC和LDL-C降低(P﹤0.05)。治疗组和对照组治疗后比较,偶测血压、24h、日间、夜间平均血压亦均下降(P﹤0.05),谷/峰比值也优于对照组(P﹤0.05)。[结论]他汀类药物在高血压患者的长期治疗过程中具有有效降低血压的作用,特别对高血压合并高血脂的患者是理想的用药选择。
[Objective] To observe the clinical efficacy and safety of simvastatin combined with valsartan in the long-term treatment of patients with mild to moderate essential hypertension. [Methods] 103 patients with mild to moderate essential hypertension were from outpatient cases in our hospital. Random numbers were generated from the recorded random number table and divided into treatment group (n = 53), control group (n = 50), treatment group Shantan and simvastatin combined with valsartan alone, 10 weeks after treatment efficacy analysis. [Results] The total effective rate was 97.1% in the treatment group and 84.0% in the control group, with significant difference between the two groups (P <0.05). The mean blood pressure of both groups were decreased (P <0.01) and TC and LDL-C decreased (P <0.05) after treatment compared with before treatment. Compared with the control group, the mean blood pressure, the average blood pressure at 24h, daytime and nighttime also decreased (P <0.05) and the ratio of valley / peak was also better than that of the control group (P <0.05). [Conclusion] Statins have an effective hypotensive effect in the long-term treatment of patients with hypertension, especially for those patients with hypertension and hyperlipidemia.