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[目的]观察瓜蒌皮注射液联合西药治疗痰瘀互结冠心病心绞痛疗效。[方法]使用随机平行对照方法,将58例住院患者按病案号抽签方法简单随机分为两组。对照组28例阿司匹林肠溶片100mg/次,1次/d,口服;阿托伐他汀20mg/次,每晚口服;单硝酸异山梨酯缓释20mg/次,2次/d,口服。治疗组30例以瓜蒌皮注射液8m L+5%的葡萄糖注射液(糖尿病+0.9%生理盐水)100m L,1次/d,静滴;西药治疗同对照组。治疗10d为1疗程。观测临床症状、体征、证候积分、心电图、同型半胱氨酸、不良反应。治疗1疗程(10d),判定疗效。随访1个月,观测不良事件。[结果]治疗组显效15例,有效13例,无效2例,加重0例,总有效率93.33%;对照组显效7例,有效13例,无效8例,加重0例,总有效率71.43%;治疗组疗效优于对照组(P<0.05)。心电图改善治疗组优于对照组(P<0.05)。中医证候积分、血浆同型半胱氨酸治疗组明显改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。[结论]瓜蒌皮注射液联合西药治疗痰瘀互结冠心病心绞痛随机平行对照研究,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of melon skin injection and western medicine on phlegm, blood stasis and coronary heart disease angina pectoris. [Methods] Using randomized parallel control method, 58 inpatients were randomly divided into two groups randomly according to the case number lottery method. In the control group, aspirin enteric-coated tablets (100 mg / time, once daily, orally) and atorvastatin 20 mg per time were orally administered orally. Isosorbide mononitrate sustained-release 20 mg twice daily was given orally. In the treatment group, 30 cases were treated with 100ml of dexamethasone and 5% dextrose injection (DM + 0.9% saline) for 1 minute, once per day, while Western medicine was given as control. Treatment for 10d for a course of treatment. Clinical symptoms, signs, syndrome scores, electrocardiogram, homocysteine, adverse reactions were observed. Treatment of a course of treatment (10d), determine the efficacy. Followed up for 1 month, observed adverse events. [Results] In the treatment group, 15 cases were markedly effective, 13 cases were effective, 2 cases were ineffective, 0 cases were aggravated, and the total effective rate was 93.33%. In the control group, 7 cases were markedly effective, 13 cases were effective, 8 were ineffective, 0 cases were aggravated and the total effective rate was 71.43% The treatment group was better than the control group (P <0.05). ECG improved treatment group than the control group (P <0.05). TCM syndrome score, plasma homocysteine treatment group significantly improved (P <0.05, P <0.01), the treatment group improved better than the control group (P <0.05, P <0.01). [Conclusion] The results of randomized and controlled study on treating patients with phlegm and blood stasis and angina pectoris angina pectoris by combining Guaguipi injection and western medicine have satisfactory curative effect and no serious adverse reactions, which deserves promotion.