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云芝多糖是从担子菌杂色云芝培养物中提出的多糖。胞内多糖(IPPV)是从云芝深层培养菌丝体细胞内提出的一种匍聚糖,小鼠口服或腹腔注射,可显著保护流感病毒静脉感染所致死亡和肝脏病理损伤,口服最小有效量500mg/kg一次或每日一次 3日都有效;腹腔注射50～200mg/kg一次有效,多次给药无效。腹腔注射100mg/kg一次,对小鼠疤疹病毒静脉注射所致死亡和肝病变有23.8～28.6％的保护作用,但无统计学意义。胞内多糖腹腔注射50mg/kg一次,可促进小鼠肝Kupfer细胞吞噬功能,防止静脉注射流感和疱疹病毒所引起的Kupfer细胞吞噬功能抑制。胞内多糖和自云芝深层培养液提出的胞外多糖(EPPV)腹腔注射小鼠,可诱生血清干扰素,胞外多糖诱生干扰素滴度高于胞内多糖。进一步工作有可能提高云芝多糖的疗效。
Coriolus versicolor is a polysaccharide proposed from the culture of Basidiomycetes versicolor. Intracellular polysaccharides (IPPV) is a kind of cane polysaccharide proposed from mycelium cells of deep culture of Yunzhi. Oral or intraperitoneal injection of mice can significantly protect the death caused by the virus infection of the influenza virus and the pathological damage of the liver, and the oral administration is the least effective The amount of 500mg / kg once or daily on the 3rd effective; intraperitoneal injection of 50 ~ 200mg / kg once effective, multiple administration ineffective. Intraperitoneal injection of 100mg / kg once, the herpes virus in mice caused by intravenous injection of death and liver lesions have 23.8 ~ 28.6% of the protective effect, but no statistically significant. Intraperitoneal injection of intracellular polysaccharide 50mg / kg once, can promote mouse liver Kupfer cell phagocytic function, prevent the intravenous injection of influenza and herpes virus caused by Kupfer cell phagocytic inhibition. Intraperitoneal polysaccharide and extracellular polysaccharide (EPPV) from the deep culture of Yun-chih mice were injected intraperitoneally to induce the serum interferon. The extracellular polysaccharide-induced interferon titers were higher than that of intracellular polysaccharides. Further work may improve the efficacy of polysaccharides.