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目的观察舍尼通联合左氧氟沙星治疗慢性非细菌性前列腺炎的临床效果。方法筛选出符合条件的患者850例,随机分为观察组428例和对照组392例。观察组前4周合用舍尼通和左氧氟沙星,后4周单用舍尼通,服用剂量为舍尼通1片/次,1天2次,左氧氟沙星0.5 g/d,每12小时1次;对照组仅前4周用左氧氟沙星0.5 g/d,每12小时1次,后4周不用任何药物。所有患者采用慢性前列腺炎症状评分方法、前列腺按摩液检查及药物不良反应评估。结果治疗后4周和8周,观察组疼痛评分降低分别为(3.4±2.3)、(5.6±2.4),排尿评分降低分别为(1.8±1.6)、(3.0±1.6);对照组疼痛评分降低分别为(2.3±2.5)、(4.2±3.0),排尿评分降低分别为(1.2±1.8),(1.9±2.5)。两组治疗前后的自身比较差异均有统计学意义(P<0.01),生活质量影响评分、卵磷脂小体、白细胞计数比较差异也均有统计学意义(P<0.05)。观察组和对照组第4周和第8周疼痛和排尿评分比较差异均有统计学意义(P<0.01或P<0.05)。无严重不良反应发生。结论舍尼通联合左氧氟沙星治疗慢性非细菌性前列腺炎疗效明显。
Objective To observe the clinical effect of senecton combined with levofloxacin in the treatment of chronic nonbacterial prostatitis. Methods A total of 850 eligible patients were screened and divided into observation group (428 cases) and control group (392 cases). The patients in the observation group were given senepine and levofloxacin for the first 4 weeks and were given senengitom for 4 weeks. The dose of senecton was 1 tablet / time, twice a day, and levofloxacin 0.5 g / d every 12 hours. Group only levofloxacin 0.5 g / d the first 4 weeks, once every 12 hours, 4 weeks without any drugs. All patients with chronic prostatitis symptom score method, prostate massage examination and adverse drug reactions assessment. Results The reduction of pain score in the observation group was (3.4 ± 2.3) and (5.6 ± 2.4) weeks after operation and (1.8 ± 1.6) and (3.0 ± 1.6) days in the observation group decreased after 4 weeks and 8 weeks respectively. The pain score of the control group was decreased (2.3 ± 2.5) and (4.2 ± 3.0), respectively. The reduction of urination scores were (1.2 ± 1.8) and (1.9 ± 2.5), respectively. There was significant difference between the two groups before and after treatment (P <0.01). There were also significant differences in quality of life score, lecithin body and white blood cell count (P <0.05). The scores of pain and urination in the observation group and the control group at 4 weeks and 8 weeks were significantly different (P <0.01 or P <0.05). No serious adverse reactions occurred. Conclusion Seneiton combined levofloxacin treatment of chronic non-bacterial prostatitis obvious effect.