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目的:观察健脾补肾中药结合动脉注入化疗治疗局部晚期乳腺癌的临床疗效及安全性。方法:将86例局部晚期乳腺癌患者随机分为治疗组与对照组,每组43例,治疗组给予健脾补肾中药口服,并采取动脉灌注化疗;对照组仅采取动脉灌注化疗,比较两组患者在治疗前后的肿瘤大小作疗效评价。结果:治疗结束后,治疗组总缓解率为67.4%,对照组总缓解率为39.5%,两组比较,差异有统计学意义(P<0.05)。两组均未出现严重心、肝、肾损害。治疗组发生胃肠道反应7例,口腔溃疡1例,脱发34例;对照组出现胃肠道反应33例;口腔黏膜反应16例,脱发37例,肢体疼痛7例,其他6例,组间差异有统计学意义(P<0.05)。结论:健脾补肾中药结合动脉注入化疗治疗局部晚期乳腺癌临床疗效良好,比单纯使用动脉注入化疗,尤其在降低不良反应方面具有明显优势。
Objective: To observe the clinical efficacy and safety of spleen and kidney combined with traditional Chinese medicine injection of chemotherapy for locally advanced breast cancer. Methods: Eighty-six patients with locally advanced breast cancer were randomly divided into treatment group and control group, with 43 cases in each group. The treatment group was treated with Jianpi Bushen Chinese medicine and chemotherapy with arterial infusion. The control group was given only arterial infusion chemotherapy. The patient’s tumor size was evaluated before and after treatment. Results: After the treatment, the total remission rate was 67.4% in the treatment group and 39.5% in the control group. There was significant difference between the two groups (P <0.05). No serious heart, liver and kidney damage occurred in both groups. In the treatment group, there were 7 cases of gastrointestinal reaction, 1 case of oral ulcer and 34 cases of hair loss. In the control group, there were 33 cases of gastrointestinal reaction, 16 cases of oral mucosal reaction, 37 cases of hair loss, 7 cases of limb pain and 6 cases of other groups. The difference was statistically significant (P <0.05). Conclusion: The effect of spleen and kidney combined with arterial infusion chemotherapy in the treatment of locally advanced breast cancer is better than that of arterial infusion chemotherapy alone, especially in reducing adverse reactions.