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Rivier 等研究了大鼠在应激时,促肾上腺皮质激素释放因子(CRF)对黄体生成激素(LH)脉冲式分泌的影响。他们选择了电休克这样一种较可靠而刺激量又易于控制的应激刺激,对去势7～10天的雄性大鼠进行实验。结果发现,在应激后5～10 min,大鼠血浆中 LH 水平显著下降(P≤0.01),并且在此后实验期间一直处于被抑制状态。在应激前5 min 给大鼠侧脑室注射一种 CRF 拮抗剂——α螺旋 oCRF 9～14后,应激
Rivier et al. Studied the effects of corticotropin-releasing factor (CRF) on the pulsatile secretion of luteinizing hormone (LH) during stress in rats. They chose a more reliable and stimulating stimulation of electrical stress and easy to control the stimulation of the castration of male rats 7 to 10 days to experiment. The results showed that the level of LH in plasma of rats decreased significantly (P <0.01) at 5 ~ 10 min after stress, and remained in the state of inhibition afterwards during the experiment. 5 min before the stress in rats to the lateral ventricle injection of a CRF antagonist - α-helix oCRF 9 ~ 14, stress