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用成年Wistar大鼠119只,分为对照组、烫伤组、烫伤西米替丁治疗组和烫伤雷尼替丁治疗组。将大鼠背部去毛浸入100℃沸水15S,制作成20％Ⅲ度烫伤动物模型。对照组大鼠则浸入37℃水中15S;治疗组的动物分别用西米替丁(0.1mg/g)和雷尼替丁(0.05mg/g)腹腔注射,每12h1次。所有动物均按烧伤面积和体重予以液体治疗。每组动物再分别在伤后第8、24和48h处死以测定胃液量、侑液氢离子浓度和胃粘膜损伤指数(根据Guth法)。实验结果:西米替丁或雷尼替丁治疗的动物,胃液氢离子浓度比烧伤组明显下降(P<0.05,P<0.01);胃粘膜损伤指数也显著下降(P<0.01)。本实验提示,H_2受体拮抗剂西米替丁和雷尼替丁对防治烧伤后应激性溃疡均有满意的效果。
A total of 119 adult Wistar rats were divided into control group, scald group, burn cimetidine group and ranitidine group. The rats back to the hair immersed in boiling water at 100 ℃ 15S, making a 20% Ⅲ degree burns animal model. The rats in the control group were immersed in water at 37 ℃ for 15 seconds. The animals in the treatment group were injected intraperitoneally with cimetidine (0.1 mg / g) and ranitidine (0.05 mg / g) once every 12 h. All animals were treated with fluid on a burn area and weight basis. Animals in each group were sacrificed at 8, 24 and 48 hours after injury respectively to determine the amount of gastric juice, fluid hydrogen ion concentration and gastric mucosal injury index (according to the Guth method). Results: Hydrogen ion concentration in gastric juice decreased significantly in cimetidine or ranitidine treated animals (P <0.05, P <0.01), and gastric mucosal lesion index decreased significantly (P <0.01). This experiment suggests that H 2 receptor antagonist cimetidine and ranitidine have a satisfactory effect on the prevention and treatment of post-burn stress ulcer.