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目的 了解难免流产患者蜕膜内淋巴细胞增殖活性及亚群的改变 ,探讨其局部免疫状况的变化。方法 采用同位素掺入法及OKT单克隆抗体 ,检测患者蜕膜内淋巴细胞增殖活性及T淋巴细胞亚群 ,并采用正常早孕妇女蜕膜作对照。结果 难免流产患者组蜕膜组织内淋巴细胞增殖活性显著高于正常早孕组蜕膜组织 (P <0 0 5 ) ,且OKT4细胞增多 (P <0 0 5 ) ,OKT8细胞减少 (P <0 0 5 ) ,OKT4/OKT8比值增大 (P <0 0 5 )。结论难免流产患者子宫蜕膜内局部的免疫功能是亢进的 ,与流产关系密切
Objective To investigate the changes of intrapleural lymphocyte proliferation and subpopulation in patients with unavoidable abortion and to explore the changes of its local immune status. Methods By isotope incorporation method and OKT monoclonal antibody, the intra-decidual decidual lymphocyte proliferation activity and T-lymphocyte subsets were detected, and the decidua of normal pregnant women were used as control. Results It was unavoidable that the proliferative activity of lymphocytes in decidua was significantly higher than that in normal pregnancy (P <0.05), OKT4 cells increased (P <0 05) and OKT8 cells decreased 5), OKT4 / OKT8 ratio increased (P <0 0 5). Conclusions It is inevitable that the local immune function in the uterine decidua of abortion patients is hyperthyroidism and closely related to abortion