论文部分内容阅读
探讨吸烟与宫内铅暴露及新生儿神经行为的关系。方法选择我院1992～1997年8～10月间足月新生儿396例，以脐血铅含量作为新生儿宫内铅暴露的指标，新生儿神经行为评分作为效应指标，评价孕妇吸烟与新生儿神经行为的关系。结果孕期被动吸烟和主动吸烟可使脐血铅水平明显升高，脐血铅含量平均值达0．52和0．61μmol／L，高于安全界限（0．48μmol／L）的新生儿分别占69％和79％。当济血钳含量高于0．48μmol／L时，对神经行为发育有显著影响，特别对行为能力中的非生物听定向反应、生物性视和听定向反应影响更明显。结论孕期被动和主动吸烟可提高济血铅水平，并进一步影响新生儿神经行为发育，特别是视和听功能。
To explore the relationship between smoking and intrauterine lead exposure and neonatal neural behavior. Methods A total of 396 full-term newborns from March to October in our hospital from 1992 to 1997 were enrolled in this study. Lead content in umbilical cord blood was taken as an indicator of intrauterine lead exposure. Neonatal neurobehavioral score was used as an index to evaluate the effect of smoking on newborns Relationship between neural behavior. Results Both passive smoking and active smoking during pregnancy could lead to a significant increase in cord blood lead levels. The average cord blood lead levels reached 0.52 and 0.61 μmol / L, respectively, while neonates above the safety margin (0.48 μmol / L) 69% and 79%. When blood hemp blood pressure clamp is higher than 0.48μmol / L, it has a significant effect on neurobehavioral development, especially for non-biological hearing-directed reactions, biological auditory and directional responses in behavioral abilities. Conclusions Passive and active smoking during pregnancy can increase blood lead level and further affect the neurobehavioral development of neonates, especially visual and auditory function.