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组织因子途径抑制物-2(tissue factor pathway inhib- itor-2,TPFI-2)又称胎盘蛋白-5(placental protein 5,pp- 5)和基质相关性丝氨酸蛋白酶抑制剂(matrix-associated serine protease inhibitor,MSPI),它是一种带有Kunitz型结构域的蛋白酶抑制剂,属于丝氨酸蛋白酶抑制物超家族成员。1979年,Jandial和Horne首次在双胞胎妊娠者体内发现该蛋白,将其命名为PP-5。后来研究发现PP-5和人组织因子途径抑制物(TFPI)的氨基酸顺
Tissue factor pathway inhibitor-2 (TPFI-2) is also called placental protein 5 (pp-5) and matrix-associated serine protease inhibitor, MSPI), a protease inhibitor with a Kunitz-type domain, belongs to the serine protease inhibitor superfamily member. In 1979, Jandial and Horne first discovered this protein in twin pregnancies and named it PP-5. Later studies found that PP-5 and human tissue factor pathway inhibitor (TFPI) amino acid sequence