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目的从结构和生物活性等方面,对近年来发现的具有抗癌活性天然大环内酯进行综述。方法通过对国内外文献的分析、整理和归纳,较为全面的介绍了具有抗癌活性天然大环内酯的研究现状。结果与结论具有抗癌活性天然大环内酯结构独特,作用机制新颖,不仅可以提供新结构类型的抗肿瘤先导化合物,而且为发现新的作用靶点提供了依据。
OBJECTIVE To review the natural macrolides with anticancer activities discovered in recent years from the aspects of structure and biological activity. Methods By analyzing, sorting and summarizing the literature both at home and abroad, the research status of natural macrolides with anticancer activity is introduced in a comprehensive way. RESULTS AND CONCLUSIONS Antitumor activity Natural macrolide has unique structure and novel mechanism of action, which not only can provide novel structural anti-tumor lead compounds, but also provide basis for discovering new target.