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新生儿单纯疱疹病毒(Herpes Simplex Virus;HSV)感染对机体所产生的并非是一般性损害,值得注意的是,既使应用抗病毒药物治疗,其死亡率与发病率仍十分显著。估计每5,000至7,500名分娩的新生儿中就发生1例新生儿HSV感染;在美国一些地区的发病率还高。大多数新生儿HSV感染系因分娩期内胎儿接触母亲生殖器分泌物所致,偶有生后接触HSV而感染者。少数婴儿在出生时或生后不久即发现有先天畸形与HSV感染,提示胎儿可能为宫内感染。资料表明,有高危自然流产史患生殖器HSV感染的病例间接表明可能发生HSV宫内感染。了解对宫内HSV感染的发病率和发病机理及弄清疾病的临床表现非常重要,因为在分
Neonatal herpes simplex virus (HSV) infection is not a general injury to the body, it is noteworthy that, even with antiviral drug treatment, the mortality and morbidity are still very significant. An estimated 1 neonatal HSV infection occurs in every 5,000 to 7,500 newborn babies born; in some parts of the United States, the incidence is high. Most newborns with HSV infection are caused by fetal contact with the mother’s genital secretions during childbirth and are occasionally exposed to HSV. A small number of infants found congenital malformations and HSV infection at birth or shortly after birth, suggesting that the fetus may be intrauterine infection. Data show that there is a high risk of spontaneous abortion in the history of genital HSV infection indirectly shows the possibility of HSV intrauterine infection. It is important to understand the incidence and pathogenesis of intrauterine HSV infection and to clarify the clinical manifestations of the disease because,