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已经证实,苯二氮(?)类抗抑郁药的清除率随年老而下降,一些学者认为老年患者首剂量应减半。本研究在健康青、老年受试者中,评价螺环癸二酮类抗抑郁新药丁螺环酮及其药理活性代谢物1-嘧啶哌嗪(1-PP)的药动学。受试者分四组:年轻男性组(YM)、年轻女性组(YF)、老年男性组(EM)和老年女性组(EF)。每组12人,均无近期疾患。禁食过夜后,第1日各例接受本品单剂量15mg,给药后24小时内取血样。第2～4日给予45mg(15mg,每8小时)。第5日再予单剂量
It has been shown that the clearance of benzodiazepines (anti-depressants) declines with age, and some scholars believe that the first dose of the elderly should be halved. This study evaluated the pharmacokinetics of buspirone and its pharmacologically active metabolite 1-pyripirone (1-PP), a new anti-depressive agent spirobutrol in healthy young and old subjects. Subjects were divided into four groups: young male (YM), young female (YF), elderly male (EM) and elderly female (EF). Each group of 12 people, no recent illness. Fasting overnight, the first day of each case received a single dose of 15mg, within 24 hours after administration of blood samples. On the second to the 4th day, 45 mg (15 mg every 8 hours) was administered. Day 5 and then to a single dose