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目的探讨体外循环心脏直视手术（ｃａｒｄｉｏｐｕｌｍｏｎａｒｙｂｙｐａｓｓｓｕｒｇｅｒｙ，ＣＰＢＳ）患者眼压（ｉｎｔｒａｏｃｕｌｅｒｐｒｅｓ－ｓｕｒｅ，ＩＯＰ）变化及术后缺血性视神经病变的原因。方法对２３例心脏病患者使用Ｓｃｈｉｔｚ眼压计分别在体外循环、转机前、转机中及停机后测量眼压。结果体外循环转机５、１０、１５及２５ｍｉｎ时眼压升高；转机４５ｍｉｎ时眼压回落接近转机前水平，转机中患者血压、红细胞压积和血清蛋白含量下降。结论在体外循环心脏直视手术中由于血液稀释、胶体渗透压下降及眼血流量增加导致眼压升高，转机中血压也明显下降，推测术后缺血性视神经病变可能与此有关。
Objective To investigate the changes of intraoclerpler-sure (IOP) and postoperative ischemic optic neuropathy in cardiopulmonary bypass bypass (CPBS) patients undergoing cardiopulmonary bypass. Methods Twenty-three patients with heart disease were measured with Schitz tonometer before cardiopulmonary bypass, before transfer, during transfer and after stop. Results IOP was increased at 5, 10, 15 and 25 minutes after cardiopulmonary bypass. The intraocular pressure (IOP) dropped back to the pre-transfer level at 45 minutes and the blood pressure, hematocrit and serum protein levels decreased during the transfer. Conclusions IOP rises due to hemodilution, decrease of colloid osmotic pressure and increase of ocular blood flow during cardiopulmonary bypass surgery. The blood pressure during transit is also obviously decreased. It is speculated that postoperative ischemic optic neuropathy may be related to this.