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目的探讨抗 CCP 抗体在类风湿关节炎(Rheumatoid arthritis,RA)中的诊断价值,抗 CCP 抗体与动脉粥样硬化及骨侵蚀的关系.方法利用 Elasa 法检测 RA 患者及健康对照组的抗 CCP 抗体,高分辨率超声测量 RA 及健康对照组的颈动脉内膜中层厚度(Carotid artery intimamedia thickness,IMT),分析抗 CCP 抗体在RA 诊断中的敏感性及特异性,RA 患者的颈动脉粥样硬化情况.X 线评估 RA 患者双手关节的骨侵蚀情况,根据抗 CCP 抗体是否阳性将 RA 患者分为两组,抗 CCP抗体阳性组和抗 CCP 抗体阴性组,比较两组的颈动脉粥样硬化及骨侵蚀发生率.结果抗 CCP 抗体诊断 RA 的敏感性75%,特异性90%.与健康对照组相比,RA患者的颈动脉内膜中层厚度增加(P <0.05),动脉粥样硬化率增加(X2=5.19,P <0.05).在 RA 患者中,与抗 CCP 抗体阴性组比较,抗 CCP 抗体阳性组的颈动脉内膜中层厚度增加(P <0.05),动脉粥样硬化率增加(X2=5.6,P <0.05),骨侵蚀率增加(X2=7.35,P <0.05).结论抗 CCP 抗体阳性的 RA 患者更易发生动脉粥样硬化及骨侵蚀.“,”Objective To investigate the diagnostic value of anti-cyclic citrulinated peptide(CCP) antibody in Rheumatoid arthritis (RA) and the relationship between anti-CCP antibody with atherosclerosis and bone erosion. Methods To detection anti- CCP antibody titer of RA patients and healthy control group by using the method of Elasa, measure carotid artery intima-media thickness (IMT) of RA and healthy control group by high resolution ultrasound. To analysis the sensitivity and specificity of anti- CCP antibody in the diagnosis of RA, carotid atherosclerosis in RA patients. X-ray evaluation bone erosion of hands joint in RA patients. according to whether anti-CCP antibody was positive, the patients with RA were divided into two groups, anti-CCP antibody positive group and anti-CCP antibody negative group, compared the incidence of carotid atherosclerosis and bone erosion of two groups. Results the sensitivity of anti-CCP antibody in the diagnosis of RA was 75%, the specificity was 90%. Compared with the healthy control group, the carotid artery intima-media thickness in patients with RA increased (P ﹤ 0.05), atherosclerosis rate increased (X2=5.19, P ﹤ 0.05). In RA patients, Compared with anti-CCP antibody negative group, carotid artery intima-media thickness of positive group increased (P ﹤ 0.05), atherosclerosis rate increased (X2=5.6, P ﹤ 0.05), bone erosion rate increased (X2=7.35, P ﹤ 0.05). Conclusion RA patients with positive anti-CCP antibody are more susceptible to atherosclerosis and bone erosion.