近来,肺表面张力与肺表面活性物质和肺发生病理生理变化的关系,甚被重视。早在1929年 Von Neegard 就认为:呼气时,肺的弹缩,除了肺组织的弹性起作用外,肺的表面张力也起同样重要作用。随后Clements 进一步证实此见解。1954年Macklins 发现肺泡表面衬有一层能使肺泡表面张力降低的粘液样薄膜。1961年 Pattle和 Thmas 证明这层薄膜就是表面活性物质, Recently, the relationship between the pulmonary surface tension and the pathophysiological changes of pulmonary surfactant and lung has been paid more attention. As early as 1929, Von Neegard suggested that lung expan- sion during exhalation, in addition to the elasticity of the lung tissue, plays an equally important role in the surface tension of the lungs. Clements further confirmed this finding. Macklins discovered in 1954 that the alveolar surface was lined with a mucoid-like membrane that reduced the surface tension of the alveoli. 1961 Pattle and Thmas proved that the film is a surface-active substance,