论文部分内容阅读
作者报告2例淋巴网细胞瘤患者用放射治疗和Mopp方案化疗(氮芥、长春新硷、甲基苄肼、强的松)后发生了弥漫性肺部疾患。经一系列肺功能检查、胸部X射线检查及直视肺活检等证实两例都有弥漫性肺间质浸润及局限性肺部疾患存在。经用肾上腺皮质激素治疗后,临床情况及肺功能等逐步好转。本文两例肺部病变范围大大超过了放射野,所以作者认为潜隐性X射线损伤所致的肺病变可能性很少,作者还排除了感染、肿瘤扩散等可能性,认为是用化疗药物,特别是甲基苄肼所产生的过敏性肺部疾患。
The authors reported diffuse lung disease in 2 patients with lymphoblastoma treated with radiotherapy and Mopp regimen (mechlorethamine, vincristine, procarbazine, prednisone). After a series of pulmonary function tests, chest X-ray examination and direct lung biopsy confirmed two cases have diffuse pulmonary interstitial infiltration and limitations of pulmonary disease exists. After treatment with adrenal cortex hormones, clinical conditions and lung function gradually improved. The two cases of lung disease in this article greatly exceeded the scope of the radiation field, so the authors believe that latent X-ray lesion caused by the possibility of lung disease is very small, the author also ruled out the possibility of infection, tumor spread, that is the use of chemotherapy drugs, In particular, procarbazine generated allergic lung disease.