将活的马尔尼菲青霉菌的分生孢子５×１０６个从尾静脉接种到Ａ组（ＢＡＬＢ／Ｃ）和Ｂ组（ＢＡＬＢ／Ｃｎｕ／ｎｕＳＩＣ）小白鼠体内，然后按时间依次处死，取其肝脏，用病理组织学及电镜的方法观察其形态学改变。结果表明，在感染早期，Ａ组和Ｂ组变化十分相似，均表现为枯否细胞的吞噬作用及肉芽肿的形成。但随着感染的进一步发展，Ａ组和Ｂ组变化十分悬殊。Ａ组肉芽肿逐渐减少，几乎消失。Ｂ组肉芽肿继续增多，几乎占据整个肝脏。这是因为吞噬孢子的巨噬细胞能否真正杀死真菌，还要依赖于小白鼠的免疫状态，特别是细胞免疫，即Ｔ淋巴细胞的调节作用 5 × 106 conidia of live Penicillium marneffei were inoculated into the BALB / C and B groups (BALB / Cnu / nuSIC) mice from the caudal vein, Sacrificed, take the liver, with histopathology and electron microscopy methods to observe the morphological changes. The results showed that in the early stages of infection, the changes in group A and group B were very similar, showing phagocytosis of Kupffer cells and granuloma formation. However, with the further development of infection, the changes in groups A and B are very poor. A group of granulomas gradually reduced, almost disappeared. Group B granulomas continued to increase, accounting for almost the entire liver. This is because phagocytic macrophages can really kill fungi, but also depends on the immune status of mice, especially cellular immunity, that is, the regulatory role of T lymphocytes