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C族GPCRs是体内重要的受体亚家族,参与众多重要的生理和病理进程。该族受体的单体包含七螺旋跨膜结构(heptahelical transmembrane domain,HD)、捕蝇草模块(venus flytrap domain,VFT)和半胱氨酸富集区(cysteine-rich domain,CRD)、C末端等多个功能域,同时形成组成性的二聚体和寡聚体。这种多功能域寡聚体结构使该家族受体的激活机制非常复杂,本文回顾和介绍了多年以来对该家族受体在单体、二聚体、寡聚体等多个层面的激活机制研究的历程和进展,同时也展望了进一步的研究方向和这些研究成果对于开发新型药物的意义。
C family of GPCRs is an important receptor subfamily of the body, involved in many important physiological and pathological processes. The monomers of this family of receptors include heptahelical transmembrane domain (HD), venus flytrap domain (VFT) and cysteine-rich domain (CRD), C End and other multiple domains, while forming a constitutive dimer and oligomer. This multidomain oligomer structure makes the activation mechanism of this family receptor very complicated. This paper reviewed and introduced the activation mechanism of this family receptor in many aspects such as monomer, dimer, oligomer and so on for many years Research progress and progress, but also prospects for further research and the significance of these findings for the development of new drugs.