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目的寻找一种灵敏度和特异度都较高的诊断方法以提高结核病的确诊率。方法收集115例患者,采用结核分枝杆菌感染T淋巴细胞斑点试验(T-Spot.TB),检测其诊断结核病的灵敏度和特异度,以及在痰涂片抗酸杆菌阴性、结核分枝杆菌培养阴性的疑似结核病例中的检出率。结果 T-Spot.TB试验灵敏度83.3%,特异度81.3%。用该方法对临床高度怀疑结核病而痰涂片抗酸杆菌阴性的患者进行诊断,并追踪观察以疗效作为标准,结果阳性率达67.9%,阴性除外结核的符合率是75.0%。结论将T-Spot.TB试验用来作为结核病诊断的辅助检查手段是可行的。
Objective To find a diagnostic method with high sensitivity and specificity to improve the diagnosis rate of tuberculosis. Methods One hundred and fifteen patients were collected. T-Spot.TB was used to detect the sensitivity and specificity of TB in diagnosis of sputum smear and negative for Mycobacterium tuberculosis, Mycobacterium tuberculosis culture Negative cases of suspected TB in the detection rate. Results T-Spot.TB test sensitivity of 83.3%, specificity of 81.3%. The method was used to diagnose patients with highly suspected tuberculosis and sputum smear-negative acid-fast bacilli, and the follow-up observation was based on the curative effect. The positive rate was 67.9% and the negative rate was 75.0%. Conclusion It is feasible to use the T-Spot.TB test as an aid in the diagnosis of tuberculosis.