1病例资料患者女性,50岁。因发现明显口干、眼干4个月,伴肉眼血尿、蛋白尿3个月入院。该患间断近端指尖关节痛,无明显晨僵及关节无红肿、畸形等,亦无脱发、口腔溃疡及光过敏反应。入院时查体:体温36.5℃,呼吸18次/min,脉率55次/min,血压180/100mmHg。双肺呼吸音粗,双肺未闻及干、湿罗音。辅助检查:尿常规:尿蛋白3+,红细胞计数19.4/HP;24h尿蛋白定量3.5g/L,ds-DNA抗体阴性,干燥综合征A抗体(++),52KDa蛋白抗体(+++), 1 case information patient female, 50 years old. Because of the obvious dry mouth, dry eyes for 4 months, with gross hematuria, proteinuria 3 months admission. The affected off-site proximal fingertips joint pain, no obvious morning stiffness and joint swelling, deformities, etc., nor hair loss, oral ulcers and light allergic reactions. Admission examination: body temperature 36.5 ℃, breathing 18 times / min, pulse rate 55 beats / min, blood pressure 180 / 100mmHg. Breath sounds coarse lungs, lungs did not smell and dry, wet rales. Assisted examination: Urine routine: urinary protein 3+, erythrocyte count 19.4 / HP; 24h urinary protein quantitation 3.5g / L, ds-DNA antibody negative, Sjogren’s syndrome A antibody (++), 52KDa ​​protein antibody (+++) ,