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目的 :探讨妥洛特罗贴剂对儿童咳嗽变异性哮喘的血清炎症因子的影响。方法 :将78例咳嗽变异性哮喘患儿分为观察组和对照组。对照组给予常规对症治疗。观察组在对照组基础上,给予妥洛特罗贴剂治疗。对比两组治疗前后肺功能(PEF、FEV1、FVC、FEV1/FVC)及炎症因子(IFN-γ、IL-4、IFN-γ/IL-4)的变化。结果 :观察组的总有效率显著高于对照组(92.31%vs 71.79%),差异有统计学意义;两组治疗后PEF、FEV1、FVC、FEV1/FVC显著升高;治疗后,观察组的PEF、FEV1、FVC、FEV1/FVC显著高于对照组,差异有统计学意义;两组治疗后IFN-γ、IFN-γ/IL-4显著升高,IL-4显著降低;治疗后,观察组的IFN-γ、IFN-γ/IL-4显著高于对照组,IL-4显著低于对照组,差异有统计学意义。结论 :妥洛特罗贴剂能显著减轻儿童咳嗽变异性哮喘的炎症反应,改善肺功能。
Objective: To investigate the effect of tulobuterol patch on serum inflammatory factors in children with cough variant asthma. Methods: 78 cases of cough variant asthma children were divided into observation group and control group. The control group was given conventional symptomatic treatment. The observation group was treated with tulobuterol patch on the basis of the control group. The changes of pulmonary function (PEF, FEV1, FVC, FEV1 / FVC) and inflammatory cytokines (IFN-γ, IL-4 and IFN-γ / IL-4) in the two groups before and after treatment were compared. Results: The total effective rate of the observation group was significantly higher than that of the control group (92.31% vs 71.79%), the difference was statistically significant; PEF, FEV1, FVC and FEV1 / FVC were significantly increased after treatment in both groups; PEF, FEV1, FVC, FEV1 / FVC were significantly higher than the control group, the difference was statistically significant; IFN-γ, IFN-γ / IL-4 significantly increased after treatment, IL-4 was significantly reduced; The levels of IFN-γ, IFN-γ / IL-4 were significantly higher in the control group than those in the control group, IL-4 was significantly lower than the control group, the difference was statistically significant. Conclusion: The tulobuterol patch can significantly reduce the inflammatory reaction of cough variant asthma in children and improve the pulmonary function.