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成年雄性SD大鼠随机分成2组,给药及对照组灌服混悬于1％CMC中之T_4,剂量为50μg/kg/d,每周6天,对照组灌服1％等量CMC,6周后表明生育力降至零即剖杀。结果表明:①两组血清FSH、LH及睾酮均无明显差异。②与对照组相比,T_4组间质细胞基础睾酮分泌和HCG刺激后睾酮分泌均明显下降。本研究表明,抗生育剂量的T_4对血中生殖激素无明显影响,但对间质细胞可能有一定的抑制作用。这在离体培养的异常环境下可能较易显示。
Adult male Sprague-Dawley rats were randomly divided into two groups. The rats in the control group were given T_4 suspended in 1% CMC at a dose of 50 μg / kg / d for 6 days a week. The control group was given 1% Six weeks later, the fertility was reduced to zero and killed. The results showed that: ① There was no significant difference in serum FSH, LH and testosterone between the two groups. ② Compared with the control group, basal testosterone secretion in the T_4 group and testosterone secretion in HCG stimulation decreased significantly. This study shows that anti-fertility dose of T_4 has no significant effect on blood reproductive hormones, but may have some inhibitory effect on interstitial cells. This may be easier to show in abnormal conditions of in vitro culture.