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为进一步明确雄性激素对老年男性冠心病的有益作用与一氧化氮（ＮＯ）／内皮衍生的松驰因子（ＥＤＲＦ）的产生有关，我们观察了睾酮对兔主动脉及培养的兔主动脉内皮细胞ＮＯ／ＥＤＲＦ产生的调控作用。采用对兔胚胎肺－６（ＲＦＬ－６）成纤维细胞ｃＧＭＰ形成的刺激作用检测ＮＯ／ＥＤＲＦ的产生。结果表明，雄性激素能刺激兔主动脉及兔主动脉内皮细胞产生ＮＯ／ＥＤＲＦ。提示对雄性激素依赖的ＥＤＲＦ产生引起的血管扩张可能是雄性激素缓解老年男性冠心病患者心绞痛症状及改善心肌缺血的机理之一。
To further clarify the beneficial effects of androgens on coronary heart disease in elderly men and the occurrence of nitric oxide (NO) / endothelium-derived relaxation factor (EDRF), we observed the effect of testosterone on rabbit aorta and cultured rabbit aortic endothelial cells NO / EDRF regulation of the role. NO / EDRF production was measured using stimulation of cGMP formation in rabbit embryonic lung-6 (RFL-6) fibroblasts. The results showed that androgen could stimulate the production of NO / EDRF in rabbit aortic and rabbit aortic endothelial cells. Suggesting that androgen-dependent EDRF-induced vasodilatation may be one of the mechanisms by which male hormones relieve angina and improve myocardial ischemia in elderly male patients with coronary heart disease.